A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Liang, Mindong; Li, Zilong; Wang, Weishan; Liu, Jiakun; Liu, Leshi; Zhu, Guoliang; Karthik, Loganathan; Wang, Man; Wang, Kefeng; Wang, Zhong; Yu, Jing; Shuai, Yuting; Yu, Jiaming; Zhang, Lu; Zhang, Lu; Yang, Zhiheng; Li, Chuan; Zhang, Qian; Shi, Tong; Zhou, Liming; Xie, Feng; Dai, Huanqin; Liu, Xueting; Zhang, Jingyu; Liu, Guang; Zhuo, Ying; Zhang, Buchang; Li, Shanshan; Li, Shanshan; Xia, Xuekui; Tong, Yaojun; Yan-wen, Liu; Alterovitz, Gil; Tan, Gao‐Yi; Zhang, Lixin; Zhang, Lixin

doi:10.1038/s41467-019-11648-1

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A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Published in Nature Communications • Aug 14, 2019

Authors:

Mindong Liang

Zilong Li

Weishan Wang

Abstract

Besides genome editing, CRISPR-Cas12a has recently been used for DNA detection applications with attomolar sensitivity but, to our knowledge, it has not been used for the detection of small molecules. Bacterial allosteric transcription factors (aTFs) have evolved to sense and respond sensitively to ...

Subject

CRISPR

Computational biology

Biosensor

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