LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury

Gooding, Jessica; Cao, Lei; Ahmed, Faihaa; Mwiza, Jean-Marie; Fernander, Mizpha; Whitaker, Courtney; Acuff, Zach; McRitchie, Susan; Sumner, Susan; Moige Ongeri, Elimelda

doi:10.1152/ajprenal.00166.2019

Public

LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury

Published in American Journal of Physiology-Renal Physiology • Aug 14, 2019

Authors:

Jessica Gooding

Lei Cao

Faihaa Ahmed

Abstract

Meprin metalloproteases have been implicated in the pathophysiology of diabetic kidney disease (DKD). Single-nucleotide polymorphisms in the meprin-β gene have been associated with DKD in Pima Indians, a Native American ethnic group with an extremely high prevalence of DKD. In African American men w...

Subject

Kidney

Internal medicine

Diabetes mellitus

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