Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

Gervason, Sylvain; Larkem, Djabir; Ben Mansour, Amir; Botzanowski, Thomas; S. Müller, Christina; Pecqueur, Ludovic; Le Pavec, Gwenaëlle; Delaunay, A; Brun, Omar; Agramunt, Jordi; Grandas, Anna; Fontecave, Marc; Schünemann, Volker; Cianférani, Sarah; Sizun, Christina; B. Tolédano, Michel; D’Autréaux, Benoît

doi:10.1038/s41467-019-11470-9

Public

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

Published in Nature Communications • Aug 8, 2019

Authors:

Sylvain Gervason

Djabir Larkem

Amir Ben Mansour

Abstract

Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects lead to severe diseases among which is Friedreich's ataxia caused by impaired expression of frataxin (FXN). Fe-S clusters are biosynthesized on the scaffold protein ISCU, with cysteine desulfurase NFS1 providing s...

Subject

Frataxin

Ferredoxin

Iron–sulfur cluster

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!