CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Vennin, Claire; Mélénec, Pauline; Rouet, Romain; Nobis, Max; Cazet, Aurélie; J. Murphy, Kendelle; Herrmann, David; A. Reed, Daniel; C. Lucas, Morghan; Warren, Sean; Elgundi, Zehra; Pinese, Mark; Kalna, Gabriella; Roden, Daniel; Samuel, Monisha; Zaratzian, Anaiis; T. Grey, Shane; Da Silva, Andrew; Leung, Wilfred; Pancreatic Genome Initiative (APGI), Australian; L. Johns, Amber; A. Chantrill, Lorraine; Chou, Angela; Steinmann, Angela; Arshi, Mehreen; Dwarte, Tanya; Froio, Danielle; Pereira, Brooke; Ritchie, Shona; R. Chambers, Cecilia; L. Metcalf, Xanthe; Waddell, Nicola; V. Pearson, John; Patch, Ann-Marie; Nones, Katia; Newell, Felicity; Mukhopadhyay, Pamela; Addala, Venkateswar; H. Kazakoff, Stephen; Holmes, Oliver; Leonard, Conrad; Wood, Scott; M. Grimmond, Sean; Hofmann, Oliver; N. Christ, Angelika; J. C. Bruxner, Timothy; S. Samra, Jaswinder; Pavlakis, Nick; A. High, Hilda; Asghari, Ray; D. Merrett, Neil; Pavey, Darren; Das, Amitabha; H. Cosman, Peter; Ismail, Kasim; O’Connnor, Chelsie; Stoita, Alina; Williams, David; Spigellman, Allan; Lam, Vincent; McLeod, Duncan; Kirk, Judy; G. Kench, James; Grimison, Peter; Cooper, Caroline; Sandroussi, Charbel; Goodwin, Annabel; Scott Mead, R.; Tucker, Katherine; Andrews, Lesley; Texler, Michael; Forest, Cindy; Epari, Krishna; Ballal, Mo; Fletcher, David; Mukhedkar, Sanjay; Zeps, Nikolajs; Beilin, Maria; Feeney, Kynan; Q. Nguyen, Nan; Ruszkiewicz, Andrew; Worthley, Chris; Chen, John; E. Brooke‐Smith, Mark; Papangelis, Virginia; D. Clouston, Andrew; P. Barbour, Andrew; J. O’Rourke, Thomas; W. Fawcett, Jonathan; Slater, Kellee; Hatzifotis, Michael; Hodgkinson, Peter; Nikfarjam, Mehrdad; R. Eshleman, James; H. Hruban, Ralph; L. Wolfgang, Christopher; T. Lawlor, Rita; Beghelli, Stefania; Corbo, Vincenzo; Scardoni, Maria; Bassi, Claudio; V. Biankin, Andrew; Dixon, Judith; B. Jamieson, Nigel; K. Chang, David; Mathivanan, Suresh; Wang, Yingxiao; W. Braithwaite, A.; Christ, Daniel; Benda, Aleš; Parkin, Ashleigh; A. Phillips, Phoebe; M. Whitelock, John; J. Gill, Anthony; J. Sansom, Owen; R. Croucher, David; L. Parker, Benjamin; Pajic, Marina; P. Morton, Jennifer; R. Cox, Thomas; Timpson, Paul

doi:10.1038/s41467-019-10968-6

Public

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Published in Nature Communications • Aug 12, 2019

Authors:

Claire Vennin

Pauline Mélénec

Romain Rouet

Abstract

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarch...

Subject

Cancer-Associated Fibroblasts

Perlecan

Stromal cell

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!