NAD + cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, S.; Burdett, Hayden; Zhang, Xiaoxiao; Manik, M.K.; Shi, Yun; Chen, Jian; Qi, Tiancong; Gilley, Jonathan; Lai, Jhih‐Siang; X. Rank, Maxwell; W. Casey, Lachlan; Gu, Weixi; J. Ericsson, Daniel; Foley, Gabriel; Hughes, Robert; Bosanac, Todd; von Itzstein, Mark; P. Rathjen, John; D. Nanson, Jeffrey; Bodén, Mikael; B. Dry, Ian; J. Williams, Simon; J. Staskawicz, Brian; P. Coleman, Michael; Ve, Thomas; N. Dodds, Peter; Kobe, Boštjan

doi:10.1126/science.aax1911

Public

NAD + cleavage activity by animal and plant TIR domains in cell death pathways

Published in Science • Aug 23, 2019

Authors:

S. Horsefield

Hayden Burdett

Xiaoxiao Zhang

Abstract

NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefie...

Subject

NAD+ kinase

Cofactor

Nicotinamide adenine dinucleotide

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