Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Qian; L. Vallerga, Costanza; M. Walker, Rosie; Lin, Tian; K. Henders, Anjali; W. Montgomery, Grant; He, Ji; Fan, Dongsheng; Fowdar, Javed; A. Kennedy, Martin; L. Pitcher, Toni; F. Pearson, John; M. Halliday, Glenda; B. Kwok, John; B. Hickie, Ian; J.G. Lewis, Simon; Anderson, Tim; A. Silburn, Peter; D. Mellick, George; E. Harris, Sarah; Redmond, Paul; D. Murray, Alison; J. Porteous, David; Haley, Chris; L. Evans, Kathryn; M. McIntosh, Andrew; Yang, Jian; Gratten, Jacob; E. Marioni, Riccardo; R. Wray, Naomi; J. Deary, Ian; F. McRae, Allan; M. Visscher, Peter

doi:10.1186/s13073-019-0667-1

Public

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Published in Genome Medicine • Aug 23, 2019

Authors:

Qian Zhang

Costanza L. Vallerga

Rosie M. Walker

Abstract

BACKGROUND: DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the actual age ('age acceleration residual', AAR) has been reported to be associated with death. However, it is currently unclear ...

Subject

dNaM

Confounding

DNA methylation

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