Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Park, Cheol; Cha, Hee‐Jae; Lee, Hyesook; Hwang-Bo, Hyun; Yeong Ji, Seon; Yeong Kim, Min; Hyun Hong, Su; Jeong, Jin-Woo; Ho Han, Min; Hyun Choi, Sung; Jin, Cheng‐Yun; Kim, Gi‐Young; Hyun Choi, Yung

doi:10.3390/antiox8090327

Public

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Published in Antioxidants • Aug 21, 2019

Authors:

Cheol Park

Hee‐Jae Cha

Hyesook Lee

Abstract

We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis. Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulat...

Subject

Genistein

Protein kinase B

PI3K/AKT/mTOR pathway

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