Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

the ENIGMA Bipolar Disorder Working Group, for; Favre, Pauline; Pauling, Melissa; Stout, Jacques; Hozer, Franz; Sarrazin, Samuel; Abé, Christoph; Alda, Martin; Alloza, Clara; Alonso-Lana, Sílvia; A. Andreassen, Ole; T. Baune, Bernhard; Benedetti, Francesco; F. Busatto, Geraldo; J. Canales‐Rodríguez, Erick; Caseras, Xavier; Chaim-Avancini, Tiffany; R. K. Ching, Christopher; Dannlowski, Udo; Deppe, Michael; T. Eyler, Lisa; Fatjó‐Vilas, Mar; Foley, Sonya; Grotegerd, Dominik; Hájek, Tomáš; K. Haukvik, Unn; M. Howells, Fleur; Jahanshad, Neda; Kugel, Harald; Vik Lagerberg, Trine; M. Lawrie, Stephen; Linke, Julia; M. McIntosh, Andrew; Melloni, Elisa; B. Mitchell, Philip; Polosan, Mircea; Pomarol‐Clotet, Edith; Repple, Jonathan; Roberts, Gloria; Roos, Annerine; G. P. Rosa, Pedro; Salvador, Raymond; Sarró, Salvador; R. Schofield, Peter; H. Serpa, Maurício; Sim, Kang; J. Stein, Dan; E. Sussmann, Jess; Temmingh, Henk; M. Thompson, Paul; Verdolini, Norma; Vieta, Eduard; Wessa, Michèle; C. Whalley, Heather; V. Zanetti, Marcus; Leboyer, Marion; Mangin, Jean‐François; Henry, Chantal; Duchesnay, Édouard; Houenou, Josselin

doi:10.1038/s41386-019-0485-6

Public

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Published in Neuropsychopharmacology • Aug 21, 2019

Authors:

for the ENIGMA Bipolar Disorder Working Group

Pauline Favre

Melissa Pauling

Abstract

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences...

Subject

Corpus callosum

Fractional anisotropy

White matter

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