Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Chen, Fei; Esmaili, Saeed; B. Rogers, Geraint; Bugianesi, Elisabetta; Petta, Salvatore; Marchesini, Giulio; Bayoumi, Ali; Metwally, Mayada; Karimi Azardaryany, Mahmoud; Coulter, Sally; M. Choo, Jocelyn; Younes, Ramy; Rosso, Chiara; Liddle, Christopher; A. Adams, Leon; Craxı̀, Antonio; George, Jacob; Eslam, Mohammed

doi:10.1002/hep.30908

Public

Lean NAFLD: A Distinct Entity Shaped by Differential Metabolic Adaptation

Published in Hepatology • Aug 23, 2019

Authors:

Fei Chen

Saeed Esmaili

Geraint B. Rogers

Abstract

BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the adult population. A significant subset of patients are lean, but their underlying pathophysiology is not well understood. APPROACH AND RESULTS: We investigated the role of bile acids (BAs) and the gut microbiome i...

Subject

Adaptation (eye)

Differential (mechanical device)

Metabolic adaptation

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