HyPhy 2.5—A Customizable Platform for Evolutionary Hypothesis Testing Using Phylogenies

L. Kosakovsky Pond, Sergei; F. Y. Poon, Art; Velazquez, Ryan; Weaver, Steven; Lance Hepler, N.; Murrell, Ben; D. Shank, Stephen; Rife Magalis, Brittany; Bouvier, Dave; Nekrutenko, Anton; R Wisotsky, Sadie; J. Spielman, Stephanie; D. W. Frost, Simon; V. Muse, Spencer

doi:10.1093/molbev/msz197

Public

HyPhy 2.5—A Customizable Platform for Evolutionary Hypothesis Testing Using Phylogenies

Published in Molecular Biology and Evolution • Aug 25, 2019

Authors:

Sergei L. Kosakovsky Pond

Art F. Y. Poon

Ryan Velazquez

Abstract

HYpothesis testing using PHYlogenies (HyPhy) is a scriptable, open-source package for fitting a broad range of evolutionary models to multiple sequence alignments, and for conducting subsequent parameter estimation and hypothesis testing, primarily in the maximum likelihood statistical framework. It...

Subject

Biology

Statistical hypothesis testing

Coevolution

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