EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Ragazzini, Roberta; Pérez-Palacios, Raquel; H. Baymaz, Irem; Diop, Seynabou; Ancelin, Katia; Zielinski, Dina; Michaud, Audrey; Givelet, Maëlle; Borsos, Máté; Aflaki, Setareh; Legoix, Patricia; W.T.C. Jansen, Pascal; Servant, Nicolas; Torres‐Padilla, Maria‐Elena; Bourc’his, Déborah; Fouchet, Pierre; Vermeulen, Michiel; Margueron, Raphaël

doi:10.1038/s41467-019-11800-x

Public

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Published in Nature Communications • Aug 26, 2019

Authors:

Roberta Ragazzini

Raquel Pérez-Palacios

Irem H. Baymaz

Abstract

The Polycomb group of proteins is required for the proper orchestration of gene expression due to its role in maintaining transcriptional silencing. It is composed of several chromatin modifying complexes, including Polycomb Repressive Complex 2 (PRC2), which deposits H3K27me2/3. Here, we report the...

Subject

PRC2

Chromatin

Polycomb-group proteins

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