Microbial metabolites control the thymic development of mucosal-associated invariant T cells

Legoux, François; Bellet, Déborah; Daviaud, Céline; El Morr, Yara; Darbois, Aurélie; Niort, Kristina; Procopio, Emanuele; Salou, Marion; Gilet, Jules; Ryffel, Bernhard; Balvay, Aurélie; Foussier, Anne; Sarkis, Manal; El Marjou, Ahmed; Schmidt, Frédéric; Rabot, Sylvie; Lantz, Olivier

doi:10.1126/science.aaw2719

Public

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

Published in Science • Aug 29, 2019

Authors:

François Legoux

Déborah Bellet

Céline Daviaud

Abstract

Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells are absent in germ-free mice, and the mechanisms b...

Subject

Biology

Immune system

T cell

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