DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

M. van der Stoel, Miesje; Schimmel, Lilian; Nawaz, Kalim; D. van Stalborch, Anne-Marieke; de Haan, Annett; Klaus‐Bergmann, Alexandra; T. Valent, Erik; S. Koenis, Duco; P. van Nieuw Amerongen, Geerten; J.M. de Vries, Carlie; de Waard, Vivian; Gloerich, Martijn; D. van Buul, Jaap; Huveneers, Stephan

doi:10.1101/755389

Public

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

Published in bioRxiv (Cold Spring Harbor Laboratory) • Sep 2, 2019

Authors:

Miesje M. van der Stoel

Lilian Schimmel

Kalim Nawaz

Abstract

Abstract YAP/TAZ signaling is crucial for sprouting angiogenesis and vascular homeostasis through the regulation of endothelial remodeling. Thus far the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear. We here identify Deleted-in-Liver-Cancer-1 (DLC1) ...

Subject

Angiogenesis

Cell biology

Sprouting angiogenesis

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