Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Ewers, Michael; Franzmeier, Nicolai; Suárez‐Calvet, Marc; Morenas‐Rodríguez, Estrella; Ángel Araque Caballero, Miguel; Kleinberger, Gernot; Piccio, Laura; Cruchaga, Carlos; Deming, Yuetiva; Dichgans, Martin; Q. Trojanowski, John; M. Shaw, Leslie; W. Weiner, Michael; Haass, Christian; Disease Neuroimaging Initiative, Alzheimer’s

doi:10.1126/scitranslmed.aav6221

Public

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Published in Science Translational Medicine • Aug 28, 2019

Authors:

Michael Ewers

Nicolai Franzmeier

Marc Suárez‐Calvet

Abstract

These results suggest that sTREM2 is associated with attenuated cognitive and clinical decline, a finding with important implications for future clinical trials targeting the innate immune response in AD.

Subject

Cognitive decline

Cerebrospinal fluid

TREM2

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