Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, Xinyi; Sun, Guangqiang; Feng, Teng; Zhang, Jing; Huang, Xun; Wang, Tao; Xie, Zuoquan; Chu, Xingkun; Yang, Jun; Wang, Huan; Chang, Shuaishuai; Gong, Yanxue; Ruan, Lingfei; Zhang, Guanqun; Yan, Siyuan; Lian, Wen; Du, Chen; Yang, Dabing; Zhang, Qingli; Lin, Feifei; Liu, Jia; Zhang, Haiyan; Ge, Changrong; Xiao, Shifu; Ding, Jian; Geng, Meiyu

doi:10.1038/s41422-019-0216-x

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Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Published in Cell Research • Sep 6, 2019

Authors:

Xinyi Wang

Guangqiang Sun

Teng Feng

Abstract

Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD ...

Subject

Neuroinflammation

Dysbiosis

Gut flora

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