CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia.

L, Xu; J, Wang; Y, Liu; L, Xie; B, Su; D, Mou; L, Wang; T, Liu; X, Wang; B, Zhang; L, Zhao; L, Hu; H, Ning; Y, Zhang; K, Deng; L, Liu; X, Lu; T, Zhang; J, Xu; C, Li; H, Wu; H, Deng; H, Chen

doi:10.1056/nejmoa1817426

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CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia.

Shared by NobleBlocks on Sep 11, 2019 • 12:00 AM UTC

Authors:

Xu L

Wang J

Liu Y

Abstract

The safety of CRISPR (clustered regularly interspaced short palindromic repeats)-based genome editing in the context of human gene therapy is largely unknown. CCR5 is a reasonable but not absolutely protective target for a cure of human immunodeficiency virus type 1 (HIV-1) infection, because CCR5-n...

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