TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

V. Guérin, Marion; Régnier, Fabienne; Feuillet, Vincent; Vimeux, Lene; Miriam Weiss, Julia; Bismuth, Georges; Altan-Bonnet, Gregoire; Guilbert, Thomas; Thoreau, Maxime; Finisguerra, Veronica; Donnadieu, Emmanuel; Trautmann, Alain; Bercovici, Nadège

doi:10.1038/s41467-019-11998-w

Public

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Published in Nature Communications • Sep 11, 2019

Authors:

Marion V. Guérin

Fabienne Régnier

Vincent Feuillet

Abstract

Abstract Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, ...

Subject

Stimulator of interferon genes

Blockade

Sting

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