A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice

Freark de Boer, Jan; Verkade, Esther; L. Mulder, Niels; de Vries, H.; Huijkman, Nicolette; Koehorst, Martijn; Boer, Theo; C. Wolters, Justina; W. Bloks, Vincent; van de Sluis, Bart; Kuipers, Folkert

doi:10.1194/jlr.ra119000243

Public

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice

Published in Journal of Lipid Research • Sep 10, 2019

Authors:

Jan Freark de Boer

Esther Verkade

Niels L. Mulder

Abstract

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestatic and metabolic diseases. However, dissimilarities...

Subject

Bile acid

Chemistry

Cell biology

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