Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

Ding, Lina; Su, Ying; Fassl, Anne; Hinohara, Kunihiko; Qiu, Xintao; W. Harper, Nicholas; Jin Huh, Sung; Bloushtain-Qimron, Noga; Jovanović, Bojana; B. Ekram, Muhammad; Zi, Xiaoyuan; C. Hines, William; Alečković, Maša; Gil Del Alcazar, Carlos; J. Caulfield, Ryan; M. Bonal, Dennis; Nguyen, Quang-Dé; F. Merino, Vanessa; Choudhury, Sibgat; Ethington, Gabrielle; Panos, Laura; D. Grant, Michael; Herlihy, William; Au, Alfred; D. Rosson, Gedge; Argani, Pedram; L. Richardson, Andrea; Dillon, Deborah; Craig Allred, D.; Babski, Kirsten; Min Hui Kim, Elizabeth; H. McDonnell, Charles; Wagner, Jon; Rowberry, Ron; Bobolis, Kristie; G. Kleer, Celina; Shelley Hwang, E.; L. Blum, Joanne; Cristea, Simona; Siciński, Piotr; Fan, Rong; W. Long, Henry; Sukumar, Saraswati; Yeon Park, So; E. Garber, Judy; J. Bissell, Mina; Yao, Jun; Polyák, Kornélia

doi:10.1038/s41467-019-12125-5

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Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

Published in Nature Communications • Sep 13, 2019

Authors:

Lina Ding

Ying Su

Anne Fassl

Abstract

Abstract Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood. Here, we investigated myoepithelial cells in normal ...

Subject

Myoepithelial cell

Ductal carcinoma

Breast cancer

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