Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment

Li, Fang; Wang, Yu; Chen, Weiliang; Wang, Dandan; Zhou, Yejuan; You, Bengang; Liu, Yang; Qu, Chenxi; Yang, Shu-di; Chen, Mengtian; Zhang, Xuenong

doi:10.7150/thno.32416

Public

Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment

Published in Theranostics • Jan 1, 2019

Authors:

Fang Li

Yu Wang

Weiliang Chen

Abstract

Combined application of siVEGF and ETO by the multi-functional NPs with excellent and on-demand properties exhibited the desired antitumor effect on the orthotopic lung tumor. Our work has significant potential in promoting combined anti-angiogenesis therapy and chemotherapy regimen for clinical NSC...

Subject

Angiogenesis

Cancer research

In vivo

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