Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

Chen, Yibing; Mi, Yanjun; Zhang, Xiaofei; Ma, Qian; Song, Yucen; Zhang, Liwei; Wang, Dandan; Xing, Jinliang; Hou, Benxin; Li, Haolong; Jin, Huan; Du, Wei; Zou, Zhengzhi

doi:10.1186/s13046-019-1413-7

Public

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

Published in Journal of Experimental & Clinical Cancer Research • Sep 13, 2019

Authors:

Yibing Chen

Yanjun Mi

Xiaofei Zhang

Abstract

BACKGROUND: Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, whether DHA causes ferroptosis in glioma cells and the potential regulatory mechanis...

Subject

GPX4

Unfolded protein response

Glioma

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!