De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Andrejeva, Gabriela; Gowan, Sharon; Lin, Gigin; LF Wong Te Fong, Anne-Christine; Shamsaei, Elham; G. Parkes, Harry; Mui, James; I. Raynaud, Florence; J. Asad, Yasmin; Vizcay‐Barrena, Gema; Nikitorowicz-Buniak, Joanna; Valenti, Melanie; Howell, Louise; A. Fleck, Roland; Martin, Lesley‐Ann; Kirkin, Vladimir; O. Leach, Martin; Chung, Yuen‐Li

doi:10.1080/15548627.2019.1659608

Public

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Published in Autophagy • Sep 13, 2019

Authors:

Gabriela Andrejeva

Sharon Gowan

Gigin Lin

Abstract

Macroautophagy/autophagy can enable cancer cells to withstand cellular stress and maintain bioenergetic homeostasis by sequestering cellular components into newly formed double-membrane vesicles destined for lysosomal degradation, potentially affecting the efficacy of anti-cancer treatments. Using 1...

Subject

Autophagy

Biology

Autophagosome

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