MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Lutzmann, Malik; Bernex, Florence; Da Costa de Jesus, Cindy; Hodroj, Dana; Marty, Caroline; Plo, Isabelle; Vainchenker, William; Tosolini, Marie; Forichon, Luc; Bret, Caroline; Queillé, Sophie; Marchive, Candice; Hoffmann, Jean‐Sébastien; Méchali, Marcel

doi:10.1016/j.celrep.2019.07.095

Public

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Published in Cell Reports • Sep 1, 2019

Authors:

Malik Lutzmann

Florence Bernex

Cindy Da Costa de Jesus

Abstract

Hematopoiesis is particularly sensitive to DNA damage. Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy. It is not known why hematopoietic cells are highly vulnerable to DNA damage. Addressing this question is complicated by the paucity of mouse models of ...

Subject

DNA damage

Cancer research

Haematopoiesis

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