Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

R. Juvvadi, Praveen; Fox, David; G. Bobay, Benjamin; J. Hoy, Michael; Gobeil, S.; A. Venters, Ronald; Chang, Zanetta; Lin, Jackie; Floyd Averette, Anna; Cole, Deborah; C. Barrington, Blake; D. Wheaton, Joshua; Ciofani, Maria; Trzoss, Michael; Li, Xiaoming; Chan Lee, Soo; Chen, Ying‐Lien; W. Mutz, Mitchell; D. Spicer, Leonard; A. Schumacher, Maria; Heitman, Joseph; J. Steinbach, William

doi:10.1038/s41467-019-12199-1

Public

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Published in Nature Communications • Sep 19, 2019

Authors:

Praveen R. Juvvadi

David Fox

Benjamin G. Bobay

Abstract

Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits complexed with FK506 and the FK506-binding pr...

Subject

Calcineurin

Cryptococcus neoformans

Aspergillus fumigatus

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