The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Loh, Chin-Yap; Chai, Jian; Tang, Ting; Fen Wong, Won; Sethi, Gautam; K. Shanmugam, Muthu; Pei Chong, Pei; Yeng Looi, Chung

doi:10.3390/cells8101118

Public

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Published in Cells • Sep 20, 2019

Authors:

Chin-Yap Loh

Jian Chai

Ting Tang

Abstract

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metas...

Subject

Epithelial–mesenchymal transition

Crosstalk

Metastasis

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