Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

Page, Elizabeth; Bancroft, Elizabeth; N. Brook, Mark; Assel, Melissa; Hassan Al Battat, Mona; Thomas, Sarah; Taylor, Natalie; Chamberlain, Anthony; Pope, Jennifer; Ní Raghallaigh, Holly; Gareth Evans, D.; Rothwell, Jeanette; Mæhle, Lovise; Marie Grindedal, Eli; A. James, Paul; Mascarenhas, Lyon; McKinley, Joanne; Side, Lucy; Thomas, Tessy; J. van Asperen, Christi; F. A. Vasen, Hans; A. Kiemeney, Lambertus; Ringelberg, Janneke; D. Jensen, Thomas; Jørn Sloth Osther, Palle; T. Helfand, Brian; Genova, Elena; A. Oldenburg, Rogier; Cybulski, Cezary; Wokołorczyk, Dominika; Ong, Kai‐Ren; Huber, Camilla; Lam, Jimmy; Taylor, Louise; Salinas, Mónica; Feliubadaló, Lídia; C. Oosterwijk, Jan; van Zelst-Stams, Wendy; Cook, Jackie; J. Rosario, Derek; M. Domchek, Susan; M. Powers, Jacquelyn; S. Buys, Saundra; O’Toole, Karen; G.E.M. Ausems, Margreet; K. Schmutzler, Rita; Rhiem, Kerstin; Izatt, Louise; Tripathi, Vishakha; R. Teixeira, Manuel; Cardoso, Marta; D. Foulkes, William; Aprikian, Armen; van Randeraad, Heleen; Davidson, Rosemarie; Longmuir, Mark; Ruijs, Mariëlle; T.J.M. Helderman van den Enden, Apollonia; A. Adank, Muriel; Williams, Rachel; Andrews, Lesley; G. Murphy, Declan; Halliday, Dorothy; Walker, Lisa; Liljegren, Annelie; Carlsson, Stefan; Azzabi, Ashraf; Jobson, Irene; Morton, Catherine; Shackleton, Kylie; Snape, Katie; Hanson, Helen; Harris, Marion; Tischkowitz, Marc; Taylor, Amy; Kirk, Judy; Susman, Rachel; Chen‐Shtoyerman, Rakefet; D. Spigelman, Allan; Pachter, Nicholas; Ahmed, Munaza; Ramón y Cajal, Teresa; Žgajnar, Janez; Brewer, Carole; Gadea, Neus; F. Brady, Angela; van Os, Theo; Gallagher, David; T. Johannsson, Oskar; Donaldson, Alan; Barwell, Julian; Nicolai, Nicola; Friedman, Eitan; Obeid, Elias; Greenhalgh, Lynn; Murthy, Vedang; Copáková, Lucia; Saya, Sibel; McGrath, John; Cooke, Peter; Rønlund, Karina; Richardson, Kate; Henderson, Alex; Teo, Soo‐Hwang; Arun, Banu; Kast, Karin; Dias, Alexander; K. Aaronson, Neil; Ardern‐Jones, Audrey; H. Bangma, Chris; Castro, Elena; Dearnaley, David; M. Eccles, Diana; Tricker, Karen; E. Eyfjörd, Jórunn; Falconer, Alison; S. Foster, Christopher; Grönberg, Henrik; C. Hamdy, Freddie; Stefánsdóttir, Vigdís; Khoo, Vincent; J. Lindeman, Geoffrey; Lubiński, Jan; Axcrona, Karol; Mikropoulos, Christos; Mitra, Anita; Moynihan, Clare; Rennert, Gad; Suri, Mohnish; Wilson, Penny; Dudderidge, Tim; Offman, Judith; Kote‐Jarai, Zsofia; J. Vickers, Andrew; Lilja, Hans; A. Eeles, Rosalind

doi:10.1016/j.eururo.2019.08.019

Public

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

Published in European Urology • Sep 16, 2019

Authors:

Elizabeth Page

Elizabeth Bancroft

Mark N. Brook

Abstract

BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. OBJECTIVE: To report the utility of PSA screening, PrCa incidence,...

Subject

Medicine

Prostate-specific antigen

Interim

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