TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

Fu, Yi; Wang, Dongdong; Wang, Huaishan; Cai, Menghua; Li, Chao; Zhang, Xue; Chen, Hui; Hu, Yu; Zhang, Xuan; Ying, Mingyao; He, Wei; Zhang, Jianmin

doi:10.1093/neuonc/noz183

Public

TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

Published in Neuro-Oncology • Sep 24, 2019

Authors:

Yi Fu

Dongdong Wang

Huaishan Wang

Abstract

BACKGROUND: The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in vivo and its role in glioma tumorigenesis remain elusive. METHODS: TSPO knockout xenograft and spontaneous mouse glioma mode...

Subject

Translocator protein

Glioma

Glycolysis

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!