Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer

Bretin, Ludovic; Pinon, Aline; Bouramtane, Soukaina; Ouk, Catherine; Richard, Laurence; Perrin, Marie-Laure; Chaunavel, Alain; Carrion, Claire; Brégier, Frédérique; Sol, Vincent; Chaleix, Vincent; Y. Léger, David; Liagre, Bertrand

doi:10.3390/cancers11101474

Public

Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer

Published in Cancers • Sep 30, 2019

Authors:

Ludovic Bretin

Aline Pinon

Soukaina Bouramtane

Abstract

Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nano...

Subject

Photodynamic therapy

In vivo

Cancer research

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