Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial

T. Davey, Richard; Fernández‐Cruz, Eduardo; Markowitz, Norman; Pett, Sarah; G. Babiker, Abdel; Wentworth, Deborah; Khurana, Surender; Engen, Nicole; M. Gordin, Fred; K. Jain, Mamta; L. Kan, Virginia; N Polizzotto, Mark; Riska, Paul; Ruxrungtham, Kiat; Temesgen, Zelalem; Lundgren, Jens; H Beigel, John; Clifford Lane, H.; D. Neaton, James; T. Davey, Richard; Fernández‐Cruz, Eduardo; Markowitz, Norman; Pett, Sarah; G. Babiker, Abdel; Wentworth, Deborah; Khurana, Surender; Engen, Nicole; M. Gordin, Fred; K. Jain, Mamta; L. Kan, Virginia; N Polizzotto, Mark; Riska, Paul; Ruxrungtham, Kiat; Temesgen, Zelalem; Lundgren, Jens; H Beigel, John; Clifford Lane, H.; D. Neaton, James; Butts, Jessica; Denning, Eileen; DuChêne, Alain; Krum, Eric; Harrison, Merrie; Meger, Sue; L Peterson, Ross; Quan, Kien; Shaughnessy, Megan; Thompson, Greg; M. Vock, David; A. Metcalf, Julia; Dewar, Robin; Ur Rehman, Tauseef; Natarajan, Ven; M. McConnell, Rose; M. Flowers, Emily; Smith, Kenny; L. Hoover, Marie; M. Coyle, Elizabeth; J. Munroe, David; Aagaard, Bitten; Pearson, Mary; Cursley, Adam; Webb, Helen; Hudson, Fleur; Russell, Charlotte; Sy, Aminata; Purvis, Cara; Jackson, Brooke; Collaço‐Moraes, Yolanda; Carey, Dianne; Robson, Rosemary; Sánchez, Adriana; Finley, Elizabeth; Sepulveda Conwell, Donna; Losso, Marcelo; Gambardella, Luciana; Abela, Cecilia; Lopez, Paco; Alonso, Helena; Touloumi, Giota; Gioukari, Vicky; Anagnostou, Olga; Avihingsanon, Anchalee; Pussadee, Kanitta; Ubolyam, Sasiwimol; Omotosho, Bola; Solórzano, Clemencia; Petersen, Tianna; Vysyaraju, Kranthi; A. Rizza, Stacey; A. Whitaker, Jennifer; Nahra, Raquel; D. Baxter, John; I. Coburn, Patricia; M. Gardner, Edward; Scott, James; Faber, Leslie; Pastor, E.; Makohon, Linda; A MacArthur, Rodger; Monique Hillman, L; J. Farrough, Marti; Polenakovik, Hari; A. Clark, Linda; J Colon, Roberto; M. Kunisaki, Ken; Deconcini, Miranda; A. Johnson, Susan; R. Wolfe, Cameron; Mkumba, Laura; Y Carbonneau, June; Morris, Alison; Fitzpatrick, Meghan; Kessinger, Cathy; A. Salata, Robert; Arters, Karen; Tasi, Catherine; J. Panos, Ralph; A. Lach, Laura; J. Glesby, Marshall; Ham, Kirsis; Hughes, Valery; T. Schooley, Robert; Crouch, D.; Muttera, Leticia; Novák, Richard; C Bleasdale, Susan; E Zuckerman, Ariel; Manosuthi, Weerawat; Thaonyen, Supeda; Chiewcharn, Thaniya; Suwanpimolkul, Gompol; Gatechumpol, Sivaporn; Bunpasang, Sirikunya; Angus, Brian; Anderson, Monique; Morgan, Marcus; Minton, Jane; N Gkamaletsou, Maria; Hambleton, J.; Price, David; Llewelyn, Martin; Sweetman, Jonathan; Carbone, Javier; Ramón Arribas, José; Montejano, Rocío; Luis Lobo Beristaín, José; Z Martinez, Iñaki; Barberán, José; Hernandez, Paola; E. Dwyer, Dominic; Kok, Jen; H. Borges, Álvaro; Brandt, Christian; Surland Knudsen, Lene; Sypsas, Nikolaos; M. Constantinou, Costas; Markogiannakis, Antonios; Zakynthinos, Spyros; Κatsaounou, Paraskevi; Kalomenidis, Ioannis; Mykietiuk, Analía; Fernanda Alzogaray, María; Obed, Mora; Moreno Macias, Laura; E Ebensrtejin, Juan; Burgoa, Patricia; C. Nannini, Esteban; Lahitte, Matías; Pérez-Patrigeón, Santiago; Arturo Martínez-Orozco, José; Pablo Ramírez-Hinojosa, Juan

doi:10.1016/s2213-2600(19)30253-x

Public

Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial

Published in The Lancet Respiratory Medicine • Sep 30, 2019

Authors:

Richard T. Davey

Eduardo Fernández‐Cruz

Norman Markowitz

Abstract

BACKGROUND: Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might have clinical benefit for patients with influenza infection, but definitive data do not exist...

Subject

Medicine

Placebo

Clinical endpoint

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