Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Menares, Evelyn; Gálvez‐Cancino, Felipe; Cáceres-Morgado, Pablo; Ghorani, Ehsan; López, Ernesto; Díaz, Ximena; Saavedra-Almarza, Juan; Figueroa, Diego; Roa, Eduardo; A. Quezada, Sergio; Lladser, Álvaro

doi:10.1038/s41467-019-12319-x

Public

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Published in Nature Communications • Sep 27, 2019

Authors:

Evelyn Menares

Felipe Gálvez‐Cancino

Pablo Cáceres-Morgado

Abstract

Abstract Tissue-resident memory CD8 + T (Trm) cells mediate potent local innate and adaptive immune responses and play a central role against solid tumors. However, whether Trm cells cross-talk with dendritic cells (DCs) to support anti-tumor immunity remains unclear. Here we show that antigen-speci...

Subject

Cytotoxic T cell

Antigen

Immunology

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