Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Yu, Tao; Gan, Shucheng; Zhu, Qingchen; Dai, Dongfang; Li, Ni; Wang, Hui; Chen, Xiaosong; Hou, Dan; Wang, Yan; Pan, Qiang; Xu, Jing; Zhang, Xingli; Liu, Junli; Pei, Siyu; Peng, Chao; Wu, Ping; Romano, Simona; Mao, Chaoming; Huang, Mingzhu; Zhu, Xiaodong; Shen, Kunwei; Qin, Jun; Xiao, Yichuan

doi:10.1038/s41467-019-12384-2

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Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Shared by NobleBlocks on Sep 25, 2019 • 12:00 AM UTC

Authors:

Tao Yu

Shucheng Gan

Qingchen Zhu

Abstract

Abstract Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is acetylated by the acetyltransferase CREB-binding protein (CBP) during macrophage activation to suppress macrophage M2 p...

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