Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization

Xu, Ruqin; Zhang, Fangcheng; Chai, Renjie; Zhou, Wenyi; Hu, Ming; Liu, Bin; Chen, Xuke; Liu, Mingke; Xu, Qiong; Liu, Ningning; Liu, Shiming

doi:10.1111/jcmm.14635

Public

Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization

Published in Journal of Cellular and Molecular Medicine • Sep 26, 2019

Authors:

Ruqin Xu

Fangcheng Zhang

Renjie Chai

Abstract

Exosomes are served as substitutes for stem cell therapy, playing important roles in mediating heart repair during myocardial infarction injury. Evidence have indicated that lipopolysaccharide (LPS) pre-conditioning bone marrow-derived mesenchymal stem cells (BMSCs) and their secreted exosomes promo...

Subject

Mesenchymal stem cell

Microvesicles

Inflammation

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