Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot

Mateo, Mathieu; Reynard, Stéphanie; Carnec, Xavier; Journeaux, Alexandra; Baillet, Nicolas; Schaeffer, Justine; Picard, Caroline; Legras‐Lachuer, Catherine; Allan, Richard; Perthame, Émeline; Hillion, Kenzo-Hugo; Pietrosemoli, Natalia; Dillies, Marie‐Agnès; Barrot, Laura; Vallvé, Audrey; Barron, Stéphane; Fellmann, Lyne; Gaillard, Jean‐Charles; Armengaud, Jean; Carbonnelle, Caroline; Raoul, Hervé; Tangy, Frédéric; Baize, Sylvain

doi:10.1126/scitranslmed.aaw3163

Public

Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot

Published in Science Translational Medicine • Oct 2, 2019

Authors:

Mathieu Mateo

Stéphanie Reynard

Xavier Carnec

Abstract

Lassa fever is a major threat in Western Africa. The large number of people living at risk for this disease calls for the development of a vaccine against Lassa virus (LASV). We generated live-attenuated LASV vaccines based on measles virus and Mopeia virus platforms and expressing different LASV an...

Subject

Nucleoprotein

Virology

Lassa virus

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