A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression

Blasco, Hélène; Patin, Franck; Descat, Amandine; Garçon, Guillaume; Corcia, Philippe; Gelé, Patrick; Lenglet, Timothée; Bede, Peter; Meininger, Vincent; Devos, David; François Gossens, Jean; Pradat, Pierre‐François

doi:10.1371/journal.pone.0198116

Public

A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression

Published in PLoS ONE • Jun 5, 2018

Authors:

Hélène Blasco

Franck Patin

Amandine Descat

Abstract

There is an urgent and unmet need for accurate biomarkers in Amyotrophic Lateral Sclerosis. A pharmaco-metabolomics study was conducted using plasma samples from the TRO19622 (olesoxime) trial to assess the link between early metabolomic profiles and clinical outcomes. Patients included in this tria...

Subject

Metabolomics

Internal medicine

Medicine

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