CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

Xie, Lin; Huang, Weibo; Fang, Zhenhua; Ding, Fan; Zou, Fei; Ma, Xiaosheng; Tao, Jie; Guo, Jingkang; Xia, Xinlei; Wang, Hongli; Yu, Zuochong; Lu, Feizhou; Jiang, Jianyuan

doi:10.1038/s41419-019-1978-2

Public

CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

Published in Cell Death and Disease • Oct 3, 2019

Authors:

Lin Xie

Weibo Huang

Zhenhua Fang

Abstract

The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD. We sued nucleus pulposus (NP) tissues of patients, tert-butyl hydroperoxide (TBHP) stimulated NP cells (NPCs), and IVD...

Subject

Mitophagy

Apoptosis

Downregulation and upregulation

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