Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

Li, Fujun; Miao, Lixia; Xue, Teng; Qin, Hao; Mondal, Santanu; R. Thompson, Paul; A. Coonrod, Scott; Liu, Xiaoqiu; Zhang, Xuesen

doi:10.1186/s13046-019-1404-8

Public

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

Published in Journal of Experimental & Clinical Cancer Research • Oct 10, 2019

Authors:

Fujun Li

Lixia Miao

Teng Xue

Abstract

BACKGROUND: Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resistance. METHODS: We first tested whether peptidylarginine deiminase 2 (PAD2) may...

Subject

Tamoxifen

Docetaxel

Cancer research

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