METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Yue, Ben; Song, Chenlong; Yang, Linxi; Cui, Ran; Cheng, Xingwang; Zhang, Zizhen; Zhao, Gang

doi:10.1186/s12943-019-1065-4

Public

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

Published in Molecular Cancer • Oct 13, 2019

Authors:

Ben Yue

Chenlong Song

Linxi Yang

Abstract

BACKGROUND: As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulat...

Subject

Chromatin immunoprecipitation

Immunoprecipitation

Biology

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