Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

Jia, Chang; Zhang, Jian; Chen, Huanwen; Zhuge, Yingzhi; Chen, Huiqiao; Qian, Fanyu; Zhou, Kailiang; Niu, Chao; Wang, Fangyan; Qiu, Huixian; Wang, Zhenquan; Xiao, Jian; Rong, Xing; Chu, Maoping

doi:10.1038/s41419-019-2021-3

Public

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

Published in Cell Death and Disease • Oct 14, 2019

Authors:

Chang Jia

Jian Zhang

Huanwen Chen

Abstract

Kawasaki disease (KD) is the most common cause of pediatric cardiac disease in developed countries, and can lead to permanent coronary artery damage and long term sequelae such as coronary artery aneurysms. Given the prevalence and severity of KD, further research is warranted on its pathophysiology...

Subject

Pyroptosis

Inflammasome

Propidium iodide

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!