Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

Chen, Changhao; Luo, Yuming; He, Wang; Zhao, Yue; Kong, Yao; Liu, Hongwei; Zhong, Guangzheng; Li, Yuting; Li, Jun; Huang, Jian; Chen, Rufu; Lin, Tianxin

doi:10.1172/jci130892

Public

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

Published in Journal of Clinical Investigation • Oct 8, 2019

Authors:

Changhao Chen

Yuming Luo

Wang He

Abstract

Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa. However, approximately 20% of BCa with LN metastasis exhibits low VEGF-C expression, suggesting a VEGF-C-independent...

Subject

Lymphangiogenesis

Metastasis

Cancer research

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