International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

M. Nievergelt, Caroline; X. Maihofer, Adam; Klengel, Torsten; G. Atkinson, Elizabeth; Chen, Chia‐Yen; W. Choi, Karmel; R. I. Coleman, Jonathan; Dalvie, Shareefa; E. Duncan, Laramie; Gelernter, Joel; F. Levey, Daniel; W. Logue, Mark; Polimanti, Renato; C. Provost, Allison; Ratanatharathorn, Andrew; B. Stein, Murray; Torres, Katy; E. Aiello, Allison; M. Almli, Lynn; B. Amstadter, Ananda; Bo Andersen, Søren; A. Andreassen, Ole; A. Arbisi, Paul; E. Ashley‐Koch, Allison; Bryn Austin, S.; Avdibegović, Esmina; Babić, Dragan; Bækvad‐Hansen, Marie; G. Baker, Dewleen; C. Beckham, Jean; J. Bierut, Laura; I. Bisson, Jonathan; P. Boks, Marco; Bolger, Elizabeth; D. Børglum, Anders; Bradley, Bekh; Brashear, Megan; Breen, Gerome; A. Bryant, Richard; C. Bustamante, Angela; Bybjerg‐Grauholm, Jonas; R. Calabrese, Joseph; Miguel Caldas‐de‐Almeida, José; M. Dale, Anders; J. Daly, Mark; P. Daskalakis, Nikolaos; Deckert, Jürgen; L. Delahanty, Douglas; F. Dennis, Michelle; G. Disner, Seth; Domschke, Katharina; Džubur Kulenović, Alma; R. Erbes, Christopher; Evans, Alexandra; A. Farrer, Lindsay; C. Feeny, Norah; D. Flory, Janine; Forbes, David; E. Franz, Carol; Galea, Sandro; E. Garrett, Melanie; Gelaye, Bizu; Geuze, Elbert; F. Gillespie, Charles; Goci Uka, Aferdita; D. Gordon, Scott; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; A. Hauser, Michael; C. Heath, Andrew; Hemmings, Sian; M. Hougaard, David; Jakovljević, Miro; Jett, Marti; O. Johnson, Eric; Jones, Ian; Jovanović, Tanja; Qin, Xuejun; G. Junglen, Angela; Karstoft, Karen‐Inge; L. Kaufman, Milissa; C. Kessler, Ronald; Khan, Alaptagin; A. Kimbrel, Nathan; P. King, Anthony; Koen, Nastassja; R. Kranzler, Henry; S. Kremen, William; R. Lawford, Bruce; A. M. Lebois, Lauren; E. Lewis, Catrin; D. Linnstaedt, Sarah; Lori, Adriana; Lugonja, Božo; J. Luykx, Jurjen; J. Lyons, Michael; L. Maples‐Keller, Jessica; R. Marmar, Charles; R. Martin, Alicia; G. Martin, Nicholas; Maurer, Douglas; Mavissakalian, Matig; C. McFarlane, Alexander; E. McGlinchey, Regina; A. McLaughlin, Katie; A. McLean, Samuel; McLeay, Sarah; Mehta, Divya; Milberg, William; W. Miller, Mark; A. Morey, Rajendra; Phillip Morris, C.; Mors, Ole; Bo Mortensen, Preben; M. Neale, Benjamin; C. Nelson, Elliot; Nordentoft, Merete; B. Norman, Sonya; O’Donnell, Meaghan; K. Orcutt, Holly; S. Panizzon, Matthew; Peters, Edward; L. Peterson, Alan; Peverill, Matthew; H. Pietrzak, Robert; A. Polusny, Melissa; P. Rice, John; Ripke, Stephan; B. Risbrough, Victoria; L. Roberts, Andrea; O. Rothbaum, Alex; O. Rothbaum, Barbara; Roy‐Byrne, Peter; Ruggiero, Ken; L. Rung, Ariane; P. F. Rutten, Bart; L. Saccone, Nancy; E. Sánchez, Sixto; Schijven, Dick; Seedat, Soraya; V. Seligowski, Antonia; S. Seng, Julia; M. Sheerin, Christina; Silove, Derrick; K. Smith, Alicia; W. Smoller, Jordan; R. Sponheim, Scott; J. Stein, Dan; S. Stevens, Jennifer; A. Sumner, Jennifer; H. Teicher, Martin; K. Thompson, Wesley; Trapido, Edward; Uddin, Monica; J. Ursano, Robert; L. van den Heuvel, Leigh; Van Hooff, Miranda; Vermetten, Eric; H. Vinkers, Christiaan; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; A. Williams, Michelle; E. Williamson, Douglas; Winternitz, Sherry; Wolf, Christiane; J. Wolf, Erika; D. Wolff, Jonathan; Yehuda, Rachel; McD. Young, Ross; A. Young, Keith; Zhao, Hongyu; A. Zoellner, Lori; Liberzon, Israel; J. Ressler, Kerry; Haas, Magali; C. Koenen, Karestan

doi:10.1038/s41467-019-12576-w

Public

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Published in Nature Communications • Oct 8, 2019

Authors:

Caroline M. Nievergelt

Adam X. Maihofer

Torsten Klengel

Abstract

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritabili...

Subject

Genome-wide association study

Meta-analysis

Genetics

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