Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

Meng, Xuan; Deng, Jian; Liu, Fang; Guo, Tao; Liu, Mengying; Dai, Peipei; Fan, Aiping; Wang, Zheng; Zhao, Yanjun

doi:10.1021/acs.nanolett.9b02904

Public

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

Published in Nano Letters • Oct 9, 2019

Authors:

Xuan Meng

Jian Deng

Fang Liu

Abstract

antitumor efficacy of the all-active nanocarrier was corroborated in a 4T1 tumor-bearing mice model regarding tumor growth suppression and animal survival rate. The coadministration of an iron chelator weakened the antitumor potency of the nanocarrier due to ferroptosis inhibition, which was support...

Subject

Nanocarriers

Photodynamic therapy

Chemistry

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