N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Chen, Rixin; Chen, Xin; Xia, Liangping; Zhang, Jiaxing; Pan, Zhizhong; Ma, Xiaodan; Han, Kai; Chen, Jiewei; Judde, Jean-Gabrie; Déas, Olivier; Wang, Feng; Ma, Ning‐Fang; Guan, Xin‐Yuan; Yun, Jing‐Ping; Wang, Feng‐Wei; Xu, Rui‐Hua; Xie, Dan

doi:10.1038/s41467-019-12651-2

Public

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Published in Nature Communications • Oct 16, 2019

Authors:

Rixin Chen

Xin Chen

Liangping Xia

Abstract

Abstract Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N 6 -methyladenosine (m 6 A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with li...

Subject

Downregulation and upregulation

Metastasis

HMGA2

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