Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Ni, Wen; Yao, Su; Zhou, Yunxia; Liu, Yuanyuan; Huang, Piao; Zhou, Aijun; Liu, Jingwen; Che, Liheng; Li, Jianming

doi:10.1186/s12943-019-1079-y

Public

Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

Published in Molecular Cancer • Oct 16, 2019

Authors:

Wen Ni

Su Yao

Yunxia Zhou

Abstract

Abstract Background YAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified transcripts of long noncoding RNAs (lncRNAs) can regulate YAP activation in cancer progression. We investigated the fun...

Subject

GAS5

Biology

Long non-coding RNA

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