Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Multiple Sclerosis Genetics Consortium, International; A. Patsopoulos, Nikolaos; E. Baranzini, Sergio; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; H. Beecham, Ashley; James, Tojo; Replogle, Joseph; S. Vlachos, Ioannis; McCabe, Cristin; H. Pers, Tune; Brandes, Aaron; White, Charles; Keenan, Brendan; Cimpean, Maria; Winn, Phoebe; Panteliadis, Ioannis-Pavlos; Robbins, Allison; F. M. Andlauer, Till; Zarzycki, Onigiusz; Dubois, Bénédicte; Goris, An; Bach Søndergaard, Helle; Sellebjerg, Finn; Soelberg Sorensen, Per; Ullum, Henrik; Wegner Thørner, Lise; Saarela, Janna; Cournu-Rebeix, Isabelle; Damotte, Vincent; Fontaine, Bertrand; Guillot-Noel, Lena; Lathrop, Mark; Vukusic, Sandra; Berthele, Achim; Pongratz, Viola; Buck, Dorothea; Gasperi, Christiane; Graetz, Christiane; Grummel, Verena; Hemmer, Bernhard; Hoshi, Muni; Knier, Benjamin; Korn, Thomas; M. Lill, Christina; Luessi, Felix; Mühlau, Mark; Zipp, Frauke; Dardiotis, Efthimios; Agliardi, Cristina; Amoroso, Antonio; Barizzone, Nadia; D. Benedetti, Maria; Bernardinelli, Luisa; Cavalla, Paola; Clarelli, Ferdinando; Comi, Giancarlo; Cusi, Daniele; Esposito, Federica; Ferrè, Laura; Galimberti, Daniela; Guaschino, Clara; A. Leone, Maurizio; Martinelli, Vittorio; Moiola, Lucia; Salvetti, Marco; Sorosina, Melissa; Vecchio, Domizia; Zauli, Andrea; Santoro, Silvia; Mancini, Nicasio; Zuccalà, Miriam; Mescheriakova, Julia; van Duijn, Cornelia; D. Bos, Steffan; G. Celius, Elisabeth; Spurkland, Anne; Comabella, Manuel; Montalban, Xavier; Alfredsson, Lars; L. Bomfim, Izaura; Gomez-Cabrero, David; Hillert, Jan; Jagodic, Maja; Lindén, Magdalena; Piehl, Fredrik; Jelčić, Ilijas; Martin, Roland; Sospedra, Mirela; Baker, Amie; Ban, Maria; Hawkins, Clive; Hysi, Pirro; Kalra, Seema; Karpe, Fredrik; Khadake, Jyoti; Lachance, Genevieve; Molyneux, Paul; Neville, Matthew; Thorpe, John; Bradshaw, Elizabeth; J. Caillier, Stacy; Calabresi, Peter; A. C. Cree, Bruce; Cross, Anne; Davis, Mary; W. I. de Bakker, Paul; Delgado, Silvia; Dembele, Marieme; Edwards, Keith; Fitzgerald, Kate; Y. Frohlich, Irene; Gourraud, Pierre-Antoine; L Haines, Jonathan; Hakonarson, Hakon; Kimbrough, Dorlan; Isobe, Noriko; Konidari, Ioanna; Lathi, Ellen; H. Lee, Michelle; Li, Taibo; An, David; Zimmer, Andrew; Madireddy, Lohith; P. Manrique, Clara; Mitrovic, Mitja; Olah, Marta; Patrick, Ellis; A. Pericak-Vance, Margaret; Piccio, Laura; Schaefer, Cathy; Weiner, Howard; Lage, Kasper; , ANZgene; , IIBDGC; , WTCCC2; Compston, Alastair; Hafler, David; F. Harbo, Hanne; L. Hauser, Stephen; Stewart, Graeme; D’Alfonso, Sandra; Hadjigeorgiou, Georgios; Taylor, Bruce; F. Barcellos, Lisa; Booth, David; Hintzen, Rogier; Kockum, Ingrid; Martinelli-Boneschi, Filippo; L. McCauley, Jacob; R. Oksenberg, Jorge; Oturai, Annette; Sawcer, Stephen; J. Ivinson, Adrian; Olsson, Tomas; L. De Jager, Philip

doi:10.1126/science.aav7188

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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Shared by NobleBlocks on Sep 27, 2019 • 12:00 AM UTC

Authors:

International Multiple Sclerosis Genetics Consortium

Nikolaos A. Patsopoulos

Sergio E. Baranzini

Abstract

Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International Multiple Sclerosis Genetics Consortium identified mo...

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