Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

A. Patsopoulos, Nikolaos; E. Baranzini, Sergio; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley; James, Tojo; M. Replogle, Joseph; S. Vlachos, Ioannis; McCabe, Cristin; H. Pers, Tune; Brandes, Aaron; C. White, Charles; T Keenan, Brendan; Cimpean, Maria; A. Winn, Phoebe; Panteliadis, Ioannis-Pavlos; Robbins, Allison; F. M. Andlauer, Till; Zarzycki, Onigiusz; Dubois, Bénédicte; Goris, An; Bach Søndergaard, Helle; Sellebjerg, Finn; Soelberg Sorensen, Per; Ullum, Henrik; Wegner Thørner, Lise; Saarela, Janna; Cournu‐Rebeix, Isabelle; Damotte, Vincent; Fontaine, Bertrand; Guillot‐Noël, Léna; Lathrop, Mark; Vukusic, Sandra; Berthele, Achim; Pongratz, Viola; Buck, Dorothea; Gasperi, Christiane; Graetz, Christiane; Grummel, Verena; Hemmer, Bernhard; Hoshi, Muni; Knier, Benjamin; Korn, Thomas; M. Lill, Christina; Luessi, Felix; Mühlau, Mark; Zipp, Frauke; Dardiotis, Efthimios; Agliardi, Cristina; Amoroso, Antonio; Barizzone, Nadia; Donata Benedetti, Maria; Bernardinelli, Luisa; Cavalla, Paola; Clarelli, Ferdinando; Comı, Gıancarlo; Cusi, Daniele; Esposito, Federica; Ferrè, Laura; Galimberti, Daniela; Guaschino, Clara; Leone, Maurizio; Martinelli, Vittorio; Moiola, Lucia; Salvetti, Marco; Sorosina, Melissa; Vecchio, Domizia; Zauli, Andrea; Santoro, Silvia; Mancini, Nicasio; Zuccalà, Miriam; Mescheriakova, Julia; M. van Duijn, Cornelia; D. Bos, Steffan; Gulowsen Celius, Elisabeth; Spurkland, Anne; Comabella, Manuel; Montalbán, Xavier; Alfredsson, Lars; Lima Bomfim, Izaura; Gómez-Cabrero, David; Hillert, Jan; Jagodic, Maja; Lindén, Magdalena; Piehl, Fredrik; Jelčić, Ilijas; Martinꝉ, Roland; Sospedra, Mirela; Baker, Amie; Ban, Maria; Hawkins, Clive; G. Hysi, Pirro; Kalra, Seema; Karpe, Fredrik; Khadake, Jyoti; Lachance, Geneviève; Molyneux, Paul; Neville, Matthew; Thorpe, John; M. Bradshaw, Elizabeth; J. Caillier, Stacy; A. Calabresi, Peter; Cree, Bruce; Cross, Anne; F. Davis, Mary; W. I. de Bakker, Paul; Delgado, Silvia; Dembele, Marieme; R. Edwards, Keith; Fitzgerald, Kate; Y. Frohlich, Irene; Gourraud, Pierre‐Antoine; L. Haines, Jonathan; Håkonarson, Håkon; Kimbrough, Dorlan; Isobe, Noriko; Konidari, Ioanna; Lathi, Ellen; Lee, Michelle; Li, Taibo; An, David; Zimmer, Andrew; Madireddy, Lohith; P. Manrique, Clara; Mitrovič, Mitja; Olah, Marta; Patrick, Ellis; A. Pericak‐Vance, Margaret; Piccio, Laura; Schaefer, Cathy; L. Weiner, Howard; Lage, Kasper; , ANZgene; , IIBDGC; , WTCCC2; Compston, Alastair; A. Hafler, David; F. Harbo, Hanne; L. Hauser, Stephen; J. Stewart, Graeme; D’Alfonso, Sandra; Hadjigeorgiou, Georgios; Taylor, Bruce; F. Barcellos, Lisa; R. Booth, David; Hintzen, Rogier; Kockum, Ingrid; Martinelli Boneschi, Filippo; L. McCauley, Jacob; R. Oksenberg, Jorge; Oturai, Annette; Sawcer, Stephen; J. Ivinson, Adrian; Olsson, Tomas; L. De Jager, Philip

doi:10.1126/science.aav7188

Public

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Published in Science • Sep 26, 2019

Authors:

Nikolaos A. Patsopoulos

Sergio E. Baranzini

Adam Santaniello

Abstract

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants w...

Subject

Multiple sclerosis

Immune system

Major histocompatibility complex

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