Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Li, Benshang; W. Brady, Samuel; Ma, Xiaotu; Shen, Shuhong; Zhang, Yingchi; Li, Yongjin; Szlachta, Karol; Dong, Li; Liu, Yu; Yang, Fan; Wang, Ningling; A. Flasch, Diane; Myers, Matthew; L. Mulder, Heather; Ding, Lixia; Liu, Yanling; Tian, Liqing; Hagiwara, Kohei; Xu, Ke; Zhou, Xin; Sioson, Edgar; Wang, Tianyi; Yang, Liu; Zhao, Jie; Zhang, Hui; Shao, Ying; Sun, Hongye; Sun, Lele; Cai, Jiaoyang; Sun, Hui-Ying; Lin, Ting-Nien; Du, Lijuan; Li, Hui; Rusch, Michael; N. Edmonson, Michael; Easton, John; Zhu, Xiaofan; Zhang, Jingliao; Cheng, Cheng; J. Raphael, Benjamin; Tang, Jingyan; R. Downing, James; B. Alexandrov, Ludmil; S. Zhou, Bin‐Bing; Pui, Ching‐Hon; J. Yang, Jun; Zhang, Jinghui

doi:10.1182/blood.2019002220

Public

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Published in Blood • Oct 24, 2019

Authors:

Benshang Li

Samuel W. Brady

Xiaotu Ma

Abstract

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alterations were enriched in 12 genes (NR3C1, NR3C2, TP53, N...

Subject

Lymphoblastic Leukemia

Acute lymphocytic leukemia

Chemotherapy

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