Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma

Lonial, Sagar; Jacobus, Susanna; Fonseca, Rafaël; Weiss, Matthias; Kumar, Shaji; Z. Orlowski, Robert; L. Kaufman, Jonathan; M. Yacoub, Abdulraheem; K. Buadi, Francis; O’Brien, Timothy; Matous, Jeffrey; M. Anderson, Daniel; Emmons, Robert; Mahindra, Anuj; I. Wagner, Lynne; V. Dhodapkar, Madhav; Vincent Rajkumar, S.

doi:10.1200/jco.19.01740

Public

Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma

Published in Journal of Clinical Oncology • Oct 25, 2019

Authors:

Sagar Lonial

Susanna Jacobus

Rafaël Fonseca

Abstract

PURPOSE Observation is the current standard of care for smoldering multiple myeloma. We hypothesized that early intervention with lenalidomide could delay progression to symptomatic multiple myeloma. METHODS We conducted a randomized trial that assessed the efficacy of single-agent lenalidomide comp...

Subject

Lenalidomide

Medicine

Multiple myeloma

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