Muscle Oxygen Supply and Use in Type 1 Diabetes, From Ambient Air to the Mitochondrial Respiratory Chain: Is There a Limiting Step?

Heyman, Elsa; Daussin, Frédéric; Wieczorek, Valerie; Caïazzo, Robert; Matran, Régis; Berthon, P.; Aucouturier, Julien; Berthoin, Serge; Descatoire, Aurélien; Leclair, Erwan; Marais, Gaëlle; Combes, Adrien; Fontaine, P.; Tagougui, Sémah

doi:10.2337/dc19-1125

Public

Muscle Oxygen Supply and Use in Type 1 Diabetes, From Ambient Air to the Mitochondrial Respiratory Chain: Is There a Limiting Step?

Published in Diabetes Care • Oct 21, 2019

Authors:

Elsa Heyman

Frédéric Daussin

Valerie Wieczorek

Abstract

OBJECTIVE Long before clinical complications of type 1 diabetes (T1D) develop, oxygen supply and use can be altered during activities of daily life. We examined in patients with uncomplicated T1D all steps of the oxygen pathway, from the lungs to the mitochondria, using an integrative ex vivo (muscl...

Subject

Medicine

Internal medicine

Endocrinology

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