Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high-performance liquid chromatography coupled to tandem mass spectrometry.

GD, Mendes; TDS, Pereira; JC, Rodrigues; EM, Santos; MR, Souza; RAB, Lopes-Martins; NJ, Antunes; RA, Moreno; Nucci G, De

doi:10.1002/bmc.4731

Public

Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high-performance liquid chromatography coupled to tandem mass spectrometry.

Shared by NobleBlocks on Jan 23, 2020 • 12:00 AM UTC

Authors:

Mendes GD

Pereira TDS

Rodrigues JC

Abstract

To assess the bioequivalence of two zolpidem hemitartrate formulations in 30 healthy volunteers. Plasma samples were obtained over a 24 h period. Plasma concentrations of zolpidem were analyzed by liquid chromatography coupled to tandem mass spectrometry with positive ion electrospray ionization usi...

Subject

Pharmacokinetics

Tandem mass spectrometry

Bioavailability

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