Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high‐performance liquid chromatography coupled to tandem mass spectrometry

Duarte Mendes, Gustavo; da Silva Pereira, Thaís; Rodrigues, Júlio; Marcílio Santos, Elaine; Rafaela Souza, Mariani; Álvaro Brandão Lopes‐Martins, Rodrigo; de Jesus Antunes, Natalícia; Agnaldo Moreno, Ronílson; De Nucci, Gilberto

doi:10.1002/bmc.4731

Public

Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high‐performance liquid chromatography coupled to tandem mass spectrometry

Published in Biomedical Chromatography • Oct 25, 2019

Authors:

Gustavo Duarte Mendes

Thaís da Silva Pereira

Júlio Rodrigues

Abstract

Abstract To assess the bioequivalence of two zolpidem hemitartrate formulations in 30 healthy volunteers. Plasma samples were obtained over a 24 h period. Plasma concentrations of zolpidem were analyzed by liquid chromatography coupled to tandem mass spectrometry with positive ion electrospray ioniz...

Subject

Bioequivalence

Chemistry

Zolpidem

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