Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis

Valès, Simon; Bacola, Gregory; Biraud, Mandy; Touvron, Mélissa; Bessard, Anne; Geraldo, Fanny; A. Dougherty, Kelsie; Lashani, Shaian; Bossard, Céline; Flamant, Mathurin; Duchalais, Émilie; Marionneau‐Lambot, Séverine; Oullier, Thibauld; Oliver, Lisa; Neunlist, Michel; M. Vallette, François; Van Landeghem, Laurianne

doi:10.1016/j.ebiom.2019.09.045

Public

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis

Published in EBioMedicine • Oct 26, 2019

Authors:

Simon Valès

Gregory Bacola

Mandy Biraud

Abstract

BACKGROUND: Colon cancer stem cells (CSCs), considered responsible for tumor initiation and cancer relapse, are constantly exposed to regulatory cues emanating from neighboring cells present in the tumor microenvironment. Among these cells are enteric glial cells (EGCs) that are potent regulators of...

Subject

Carcinogenesis

Stem cell

Colorectal cancer

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