Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Van Steenwinckel, Juliette; Schang, Anne‐Laure; L. Krishnan, Michelle; Degos, Vincent; Delahaye‐Duriez, Andrée; Bokobza, Cindy; Csaba, Zsolt; Verdonk, Franck; Montané, Amélie; Sigaut, Stéphanie; Hennebert, Olivier; Lebon, Sophie; Schwendimann, Leslie; Le Charpentier, Tifenn; Hassan-Abdi, Rahma; Ball, Gareth; Aljabar, Paul; Saxena, Alka; Holloway, R.; Birchmeier, Walter; Baud, Olivier; H. Rowitch, David; E. Miron, Véronique; Chrétien, Fabrice; Leconte, Claire; C. Besson, Valérie; Petretto, Enrico; David Edwards, A.; Hagberg, Henrik; Soussi‐Yanicostas, Nadia; Fleiss, Bobbi; Gressèns, Pierre

doi:10.1093/brain/awz319

Public

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Published in Brain • Oct 1, 2019

Authors:

Juliette Van Steenwinckel

Anne‐Laure Schang

Michelle L. Krishnan

Abstract

Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants is associated with permanent neurological sequelae in 9 million infants e...

Subject

Microglia

Neuroinflammation

Wnt signaling pathway

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